IN-INTO Into DT a CD 10 NN-VOL mL NN-PRESSURE pressure NN-APPARATUS vessel VB-APPARATUS equipped IN-WITH with DT a JJ magnetic JJ-CHEM stir NN-APPARATUS bar VBD was VB-SUSPEND placed CD 0.1 NN-MASS g -LRB- ( CD .266 NN-AMOUNT mmol -RRB- ) OSCAR-CM 5-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide -LRB- ( VB see NN-EXAMPLE Example CD 126 -RRB- ) COMMA , CD 0.031 NN-MASS g -LRB- ( CD .27 NN-AMOUNT mmol -RRB- ) OSCAR-CM N,N-dimethyl-2-(methylamino)acetamide COMMA , CD .726 NN-VOL mL -LRB- ( CD .8 NN-AMOUNT mmol -RRB- ) OSCAR-CM N,N-diisopropylethylamine CC and CD 5 NN-VOL mL OSCAR-CM DMF STOP . DT-THE The NN-APPARATUS vessel VBD was VB-APPARATUS sealed CC and VB-HEAT heated IN-ON on DT an NN-STATE oil NN-APPARATUS bath TO to CD 135 NN-TEMP °C IN-FOR for CD 18 NN-TIME hrs STOP . COMMA , IN-AFTER after WDT which DT-THE the NN-CHEMENTITY mixture VBD was VB-COOL cooled CC and DT-THE the NN-CHEMENTITY solvent VB-REMOVE removed IN-IN in NN-VACUUM vacuo STOP . DT-THE The NN-CHEMENTITY residue VBD was VB-PURIFY purified IN-BY by JJ reverse NN-CHEMENTITY phase NNP HPLC IN-ON on DT a OSCAR-CM C18 NN-COLUMN column VB-USE using OSCAR-CM acetonitrile DASH / OSCAR-CM water IN-AS as NN-CHEMENTITY eluent TO to VB-YIELD give OSCAR-CM 5-[[2-(dimethylamino)-2-oxoethyl](methyl)amino]-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide STOP .